When taking Anastrozole, it's essential to avoid certain foods that may interfere with the medication's effectiveness. Foods to avoid when taking Anastrozole include those high in phytoestrogens, such as soy products (tofu, soy milk) and flaxseeds, as they can mimic estrogen in the body. Cruciferous vegetables like broccoli and kale, when consumed in excess, may also impact Anastrozole’s function. Alcohol should be limited since it can increase estrogen levels, counteracting the drug’s effect. High-caffeine drinks, such as coffee, may worsen side effects like hot flashes.